DOI: 10.1515/mr-2021-0002
The gut-cardiovascular connection:new era for cardiovascular therapy
Chak Kwong Cheng1
Yu Huang2
1.School of Biomedical Sciences and Li Ka Shing Institute of Health Science;The Chinese University of Hong Kong,Hong Kong SAR 999077,China;Heart and Vascular Institute and Shenzhen Research Institute,The Chinese University of Hong Kong,Hong Kong SAR 999077,China2.School of Biomedical Sciences and Li Ka Shing Institute of Health Science;The Chinese University of Hong Kong,Hong Kong SAR 999077,China;Heart and Vascular Institute and Shenzhen Research Institute;The Chinese University of Hong Kong,Hong Kong SAR 999077,China
摘要：Our gut microbiome is constituted by trillions of microorganisms including bacteria,archaea and eukary-otic microbes.Nowadays,gut microbiome has been grad-ually recognized as a new organ system that systemically and biochemically interact with the host.Accumulating evidence suggests that the imbalanced gut microbiome contributes to the dysregulation of immune system and the disruption of cardiovascular homeostasis.Specific micro-biome profiles and altered intestinal permeability are often observed in the pathophysiology of cardiovascular diseases.Gut-derived metabolites,toxins,peptides and immune cell-derived cytokines play pivotal roles in the induction of inflammation and the pathogenesis of dysfunction of heart and vasculature.Impaired crosstalk between gut microbiome and multiple organ systems,such as gut-vascular,heart-gut,gut-liver and brain-gut axes,are associated with higher cardiovascular risks.Medications and strategies that restore healthy gut microbiome might therefore represent novel therapeutic options to lower the incidence of cardiovascular and metabolic disorders.
机标关键词：connectioncardiovasculartherapy
论文发表日期：2021-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：24( 23-46 )
英文信息