DOI: 10.1515/mr-2021-0005
The role of caveolae in endothelial dysfunction
Jinlong He1
Zhen Cui1
Yi Zhu2
1.Tianjin Key Laboratory of Metabolic Diseases,The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics and Department of Physiology and Pathophysiology,Tianjin Medical University,Tianjin 300070,China2.Department of Physiology and Pathophysiology,Tianjin Medical University,22 Qixiangtai Rd,Tianjin 300070,China
摘要：Caveolae,the specialized cell-surface plasma membrane invaginations which are abundant in endothe-lial cells,play critical roles in regulating various cellular processes,including cholesterol homeostasis,nitric oxide production,and signal transduction.Endothelial caveolae serve as a membrane platform for compartmentalization,modulation,and integration of signal events associated with endothelial nitric oxide synthase,ATP synthase β,and integrins,which are involved in the regulation of endo-thelial dysfunction and related cardiovascular diseases,such as atherosclerosis and hypertension.Furthermore,these dynamic microdomains on cell membrane are modulated by various extracellular stimuli,including cholesterol and flow shear stress.In this brief review,we summarize the critical roles of caveolae in the orchestra-tion of endothelial function based on recent findings as well as our work over the past two decades.
机标关键词：caveolaeroledysfunctionendothelial
论文发表日期：2021-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 78-91 )
英文信息