DOI: 10.1515/mr-2021-0015
Connections between metabolism and epigenetic modifications in cancer
Guangchao Wang1
Jingdong J.Han2
1.Peking-Tsinghua Center for Life Sciences,Academy for Advanced Interdisciplinary Studies,Center for Quantitative Biology(CQB),Peking University,Beijing,China2.Peking-Tsinghua Center for Life Sciences,Academy for Advanced Interdisciplinary Studies,Center for Quantitative Biology(CQB),Peking University,5 Yiheyuan Rd,Haidian District,Beijing 100871,China
摘要：How cells sense and respond to environmental changes is still a key question.It has been identified that cellular metabolism is an important modifier of various epigenetic modifications,such as DNA methylation,histone methylation and acetylation and RNA N6-methyladenosine(m6A)methylation.This closely links the environmental nutrient availability to the maintenance of chromatin struc-ture and gene expression,and is crucial to regulate cellular homeostasis,cell growth and differentiation.Cancer meta-bolic reprogramming and epigenetic alterations are widely observed,and facilitate cancer development and progres-sion.In cancer cells,oncogenic signaling-driven metabolic reprogramming modifies the epigenetic landscape via changes in the key metabolite levels.In this review,we briefly summarized the current evidence that the abundance of key metabolites,such as S-adenosyl methionine(SAM),acetyl-CoA,α-ketoglutarate(α-KG),2-hydroxyglutarate(2-HG),uri-dine diphospho-N-acetylglucosamine(UDP-GlcNAc)and lactate,affected by metabolic reprogramming plays an important role in dynamically regulating epigenetic modifi-cations in cancer.An improved understanding of the roles of metabolic reprogramming in epigenetic regulation can contribute to uncover the underlying mechanisms of meta-bolic reprogramming in cancer development and identify the potential targets for cancer therapies.
机标关键词：betweencancerconnectionsepigeneticmetabolismmodifications
论文发表日期：2021-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：23( 199-221 )
英文信息