DOI: 10.1515/mr-2021-0014
Tumor-associated macrophages,dendritic cells,and neutrophils:biological roles,crosstalk,and therapeutic relevance
Mingyi Shen1
Yanhua Du2
Youqiong Ye2
1.Department of Immunology and Microbiology,Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine,Shanghai,China2.Department of Immunology and Microbiology,Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
摘要：Tumor-associated myeloid cells constitute a series of plastic and heterogeneous cell populations within the tumor microenvironment(TME),and exhibit different phenotypes and functions in response to various microenvironmental signals.In light of prom-ising preclinical data indicating that myeloid-based therapy can effectively suppress tumor growth,a series of novel immune-based therapies and approaches are currently undergoing clinical evaluation.A better un-derstanding of the diversity and functional roles of different myeloid cell subtypes and of how they are associated with TME remodeling may help to improve cancer therapy.Herein,we focus on myeloid cells and discuss how tumor cells can simultaneously reprogram these cells through tumor-derived factors and metabo-lites.In addition,we discuss the interactions between myeloid cells and other cells in the TME that have the potential to directly or indirectly regulate tumor initia-tion,invasion,or angiogenesis.We further discuss the current and future potential applications of myeloid cells in the development of focused therapeutic strategies in cancer treatment.
机标关键词：crosstalkcellstumorassociatedbiologicaldendriticmacrophagesneutrophils
论文发表日期：2021-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：22( 222-243 )
英文信息