DOI: 10.1515/mr-2021-0011
Nano drug delivery systems improve metastatic breast cancer therapy
Runqi Zhu1
Tianqun Lang2
Qi Yin3
Yaping Li3
1.State Key Laboratory of Drug Research&Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,China;University of Chinese Academy of Sciences,Beijing,China2.State Key Laboratory of Drug Research&Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,China;University of Chinese Academy of Sciences,Beijing,China;Yantai Key Laboratory of Nanomedicine&Advanced Preparations,Yantai Institute of Materia Medica,Yantai,Shandong Province,China3.State Key Laboratory of Drug Research&Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,501 Haike Road,Shanghai 201203,China
摘要：Despite continual progress in the technologies and regimens for cancer therapy,the treatment outcome of fatal metastatic breast cancer is far from satisfactory.Encouragingly,nanotechnology has emerged as a valuable tool to optimize drug delivery process in cancer therapy via preventing the cargos from degradation,improving the tumor-targeting efficiency,enhancing therapeutic agents'retention in specific sites,and controlling drug release.In the last decade,several mechanisms of suppressing tumor metastasis by functional nano drug delivery systems(NDDSs)have been revealed and a guidance for the rational design of anti-metastasis NDDSs is summarized,which consist of three aspects:optimization of physi-ochemical properties,tumor microenvironment remodel-ing,and biomimetic strategies.A series of medicinal functional biomaterials and anti-metastatic breast cancer NDDSs constructed by our team are introduced in this re-view.It is hoped that better anti-metastasis strategies can be inspired and applied in clinic.
机标关键词：improvesystemscancernanobreastdeliverydrugmetastatic
论文发表日期：2021-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：31( 244-274 )
英文信息