DOI: 10.1515/mr-2021-0034
Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic
Yutong Wang1
Ke Zheng1
Wenjing Gao2
Jun Lv3
Canqing Yu3
Lan Wang4
Zijun Wang5
Bo Wang6
Chunxiao Liao3
Liming Li7
1.Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing,China2.Department of Epidemiology and Biostatistics,School of Public Health,Peking University,38 Xueyuan Road,Haidian District,Beijing 100191,China3.Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing,China;Peking University Centre for Public Health and Epidemic Preparedness and Response,Beijing,China4.National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing,China5.Peking University Centre for Public Health and Epidemic Preparedness and Response,Beijing,China6.Meinian Public Health Institute,Peking University Health Science Center,Beijing,China7.Department of Epidemiology and Biostatistics,School of Public Health,Peking University,38 Xueyuan Road,Haidian District,Beijing 100191,China;Peking University Centre for Public Health and Epidemic Preparedness and Response,Beijing 100191,China
摘要：With the presence of Coronavirus Disease 2019(COVID-19)asymptomatic infections detected,their pro-portion,transmission potential,and other aspects such as immunity and related emerging challenges have attracted people's attention.We have found that based on high-quality research,asymptomatic infections account for at least one-third of the total cases,whereas based on sys-tematic review and meta-analysis,the proportion is about one-fifth.Evaluating the true transmission potential of asymptomatic cases is difficult but critical,since it may affect national policies in response to COVID-19.We have summarized the current evidence and found,compared with symptomatic cases,the transmission capacity of asymptomatic individuals is weaker,even though they have similar viral load and relatively short virus shedding duration.As the outbreak progresses,asymptomatic in-fections have also been found to develop long COVID-19.In addition,the role of asymptomatic infection in COVID-19 remains to be further revealed as the severe acute respi-ratory syndrome coronavirus 2(SARS-CoV-2)variants continue to emerge.Nevertheless,as asymptomatic in-fections transmit the SARS-CoV-2 virus silently,they still pose a substantial threat to public health.Therefore,it is essential to conduct screening to obtain more knowledge about the asymptomatic infections and to detect them as soon as possible;meanwhile,management of them is also a key point in the fight against COVID-19 community transmission.The different management of asymptomatic infections in various countries are compared and the expe-rience in China is displayed in detail.
机标关键词：asymptomaticcoronavirusdiseaseinfectionpandemicpre-symptomatic
论文发表日期：2022-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：23( 66-88 )
英文信息