DOI: 10.1515/mr-2022-0013
Peripheral mechanisms of chronic pain
Qin Zheng1
Xintong Dong2
Dustin P.Green3
Xinzhong Dong4
1.Department of Anesthesiology and Critical Care Medicine,School of Medicine,Johns Hopkins University,Room:Hunterian 814,725 N.Wolfe St.,Baltimore,MD 21205,USA2.The Solomon H.Snyder Department of Neuroscience,School of Medicine,Johns Hopkins University,Baltimore,MD,USA3.Department of Neuroscience,Cell Biology,and Anatomy,University of Texas Medical Branch,Galveston,TX,USA4.The Solomon H.Snyder Department of Neuroscience,School of Medicine,Johns Hopkins University,Room:Hunterian 817,725 N.Wolfe St.,Baltimore,MD 21205,USA;Howard Hughes Medical Institute,School of Medicine,Johns Hopkins University,Baltimore,MD 21209,USA
摘要：Acutely,pain serves to protect us from poten-tially harmful stimuli,however damage to the somato-sensory system can cause maladaptive changes in neurons leading to chronic pain.Although acute pain is fairly well controlled,chronic pain remains difficult to treat.Chronic pain is primarily a neuropathic condition,but studies examining the mechanisms underlying chronic pain are now looking beyond afferent nerve lesions and exploring new receptor targets,immune cells,and the role of the autonomic nervous system in contributing chronic pain conditions.The studies outlined in this review reveal how chronic pain is not only confined to alterations in the nervous system and presents findings on new treatment targets and for this debilitating disease.
机标关键词：chronicmechanismspainperipheral
论文发表日期：2022-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：20( 251-270 )
英文信息