DOI: 10.1515/mr-2022-0007
Spontaneous pain as a challenge of research and management in chronic pain
Longyu Ma1
Shuting Liu1
Ming Yi2
You Wan2
1.Neuroscience Research Institute and Department of Neurobiology,School of Basic Medical Sciences,Peking University,Beijing,China2.Department of Neurobiology,School of Basic Medical Sciences,Neuroscience Research Institute,Peking University,38 Xueyuan Road,Beijing 100083,China;Key Laboratory for Neuroscience,Ministry of Education/National Health Commission,Peking University,Beijing,100083,China
摘要：Spontaneous pain occurring without apparent external stimuli,is a significant complaint of individuals with chronic pain whose mechanisms,somewhat surpris-ingly,remain poorly understood.Over the past decades,neuroimaging studies start to reveal brain activities accompanying spontaneous pain.Meanwhile,a variety of animal models and behavioral tests have been established,including non-reflexive tests and free-choice tests,which have been shown to be effective in assessing spontaneous pain.For the spontaneous pain mechanisms,multiple lines of research mainly focus on three aspects:(1)sensitization of peripheral nociceptor receptors and ion channels,(2)spontaneous neuronal firing and abnormal activity patterns at the dorsal root ganglion and spinal cord level,(3)func-tional and structural alterations in the brain,particularly the limbic system and the medial pain pathway.Despite accu-mulating evidence revealing distinct neuronal mechanisms from evoked pain,we are still far from full understanding of spontaneous pain,leaving a big gap between bench and bedside for chronic pain treatment.A better understanding of the neural processes in chronic pain,with specific linkage as to which anatomical structures and molecules related to spontaneous pain perception and comorbidities,will greatly improve our ability to develop novel therapeutics.
机标关键词：managementresearchchallengechronicpainspontaneous
论文发表日期：2022-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 308-319 )
英文信息