DOI: 10.1515/mr-2022-0023
The polarizable and reprogrammable identity of Kupffer cells in Nonalcoholic Steatohepatitis
Tarik Zahr1
Kevin Sun2
Li Qiang3
1.Naomi Berrie Diabetes Center,Columbia University,New York,NY,USA;Department of Molecular Pharmacology and Therapeutics,Columbia University,New York,NY,USA2.Department of Pathology and Cell Biology,Columbia University,New York,NY,USA3.Naomi Berrie Diabetes Center,Columbia University,1150 St.Nicholas Ave,New York,NY 10032,USA;Department of Pathology and Cell Biology,Columbia University,New York,NY 10032,USA
摘要：Kupffer cells(KCs)are the resident macrophages of the liver with similar origins to myeloid-derived mac-rophages.Once differentiated,KCs exhibit distinct cellular machinery capable of longevity and self-renewal,making them a crucial player in promoting effective intrahepatic communication.However,this gets compromised in dis-ease states like Nonalcoholic Steatohepatitis(NASH),where the loss of embryo-derived KCs(EmKCs)is observed.Despite this,other KC-like and KC-derived populations start to form and contribute to a variety of roles in NASH pathogenesis,often adopting a NASH-associated molecu-lar signature.Here we offer a brief overview of recent re-ports describing KC polarization and reprogramming in the liver.We describe the complexities of KC cellular identity,their proposed ability to reprogram to fibroblast-like and endothelial-like cells,and the potential implications in NASH.
机标关键词：kupffercellsidentitynonalcoholicpolarizablereprogrammablesteatohepatitis
论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 324-327 )
英文信息