DOI: 10.1515/mr-2022-0018
Crosstalk between bone and other organs
Wanqiong Yuan1
Chunli Song2
1.Department of Orthopedics,Peking University Third Hospital,Beijing,China;Beijing Key Laboratory of Spinal Disease,Beijing,China;Engineering Research Center of Bone and Joint Precision Medicine,Beijing,China2.Department of Orthopedics,Peking University Third Hospital,No.49,North Garden Road,Haidian District,Beijing 100919,China
摘要：Bone has long been considered as a silent organ that provides a reservoir of calcium and phosphorus,traditionally.Recently,further study of bone has revealed additional functions as an endocrine organ connecting systemic organs of the whole body.Communication between bone and other organs participates in most physiological and pathological events and is responsible for the maintenance of homeostasis.Here,we present an overview of the crosstalk between bone and other organs.Furthermore,we describe the factors mediating the cross-talk and review the mechanisms in the development of potential associated diseases.These connections shed new light on the pathogenesis of systemic diseases and provide novel potential targets for the treatment of systemic diseases.
机标关键词：crosstalkbetweenboneorgansother
论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：18( 331-348 )
英文信息