DOI: 10.1515/mr-2022-0017
Leptin signaling and leptin resistance
Jiarui Liu1
Futing Lai1
Yujia Hou1
Ruimao Zheng2
1.Department of Anatomy,Histology and Embryology,School of Basic Medical Sciences,Health Science Center,Peking University,Beijing,China2.Department of Anatomy,Histology and Embryology,School of Basic Medical Sciences,Health Science Center,Peking University,Beijing 100191,China;Neuroscience Research Institute,Peking University,Beijing 100191,China;Key Laboratory for Neuroscience of Ministry of Education,Peking University,Beijing 100191,China;Key Laboratory for Neuroscience of National Health Commission,Peking University,NO.38 Xueyuan Road,Beijing 100191,China
摘要：With the prevalence of obesity and associated comorbidities,studies aimed at revealing mechanisms that regulate energy homeostasis have gained increasing interest.In 1994,the cloning of leptin was a milestone in metabolic research.As an adipocytokine,leptin governs food intake and energy homeostasis through leptin receptors(LepR)in the brain.The failure of increased leptin levels to suppress feeding and elevate energy expenditure is referred to as leptin resistance,which encompasses complex pathophysiological processes.Within the brain,LepR-expressing neurons are distributed in hypothalamus and other brain areas,and each population of the LepR-expressing neurons may mediate particular aspects of leptin effects.In LepR-expressing neurons,the binding of leptin to LepR initiates multiple signaling cascades including janus kinase(JAK)-signal transducers and acti-vators of transcription(STAT)phosphatidylinositol 3-ki-nase(PI3K)-protein kinase B(AKT),extracellular regulated protein kinase(ERK),and AMP-activated protein kinase(AMPK)signaling,etc.,mediating leptin actions.These findings place leptin at the intersection of metabolic and neuroendocrine regulations,and render leptin a key target for treating obesity and associated comorbidities.This review highlights the main discoveries that shaped the field of leptin for better understanding of the mechanism governing metabolic homeostasis,and guides the development of safe and effective interventions to treat obesity and associated diseases.
机标关键词：leptinresistancesignaling
论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：22( 363-384 )
英文信息