DOI: 10.1515/mr-2022-0009
Potential diagnostic biomarkers for schizophrenia
Weihua Yue1
Hailiang Huang2
Jubao Duan3
1.Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder,Chinese Academy of Medical Sciences(2018RU006),Institute of Mental Health,Peking University Sixth Hospital,No.51 Hua Yuan Bei Road,Beijing,100191,China;National Clinical Research Center for Mental Disorders & NHC Key Laboratory of Mental Health (Peking University),Beijing,100191,China;PKU-IDG/McGovern Institute for Brain Research,Peking University,Beijing,100871,China;Chinese Institute for Brain Research,Beijing,102206,China2.Analytic and Translational Genetics Unit,Massachusetts General Hospital,Boston,MA,USA;Stanley Center for Psychiatric Research,Broad Institute of MIT and Harvard,Cambridge,MA,USA;Department of Medicine,Harvard Medical School,Boston,MA,USA3.Center for Psychiatric Genetics,NorthShore University Health System,Evanston,IL,USA;Department of Psychiatry and Behavioral Neurosciences,University of Chicago,Chicago,IL,USA
摘要：Schizophrenia(SCH)is a complex and severe mental disorder with high prevalence,disability,mor-tality and carries a heavy disease burden,the lifetime prevalence of SCH is around 0.7%-1.0%,which has a profound impact on the individual and society.In the clinical practice of SCH,key problems such as subjective diagnosis,experiential treatment,and poor overall prognosis are still challenging.In recent years,some exciting discoveries have been made in the research on objective biomarkers of SCH,mainly focusing on genetic susceptibility genes,metabolic indicators,immune indices,brain imaging,electrophysiological character-istics.This review aims to summarize the biomarkers that may be used for the prediction and diagnosis of SCH.
机标关键词：schizophreniadiagnosticbiomarkerspotential
论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：32( 385-416 )
英文信息