DOI: 10.1515/mr-2022-0006
Astrocytes:the neglected stars in the central nervous system and drug addiction
Wenjun Chen1
Shiqiu Meng1
Ying Han1
Jie Shi2
1.National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence,Peking University,Beijing,China2.National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence,Peking University,Beijing 100191,China;The State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100191,China;The Key Laboratory for Neuroscience of the Ministry of Education and Health,Peking University,Beijing 100191,China
摘要：With the advent of improved tools to examine the astrocytes,which have been believed to play a supportive role in the central nervous system(CNS)for years,their participation in the operation of the CNS and drug addiction was unveiled.Assisting the formation and function of the CNS,astrocytes are involved in physiological and patholog-ical brain activities.Drug addiction is a pervasive psychiatric disorder,characterized by compulsive drug-taking behavior and high rate of relapse,impacting individual health and society stability and safety.When exposed to drugs of abuse,astrocytes go through a series of alterations,contributing to the development of addiction.Here we review how astrocytes contribute to the CNS and drug addiction.We hope that understanding the interaction between addictive drugs and astrocytes may help discover new mechanisms underlying the addiction and produce novel therapeutic treatments.
机标关键词：centralsystemaddictionastrocytesdrugneglectednervousstars
论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 417-426 )
英文信息