DOI: 10.1515/mr-2022-0016
Proteomics research of SARS-CoV-2 and COVID-19 disease
Nan Zhang1
Siyuan Wang2
Catherine C.L.Wong3
1.Department of Medical Research Center,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing,P.R.China;Department of Radiation Oncology,College of Medicine,The Ohio State University,Columbus,OH,USA;Center for Cancer Metabolism,Comprehensive Cancer Center,The Ohio State University,Columbus,OH,USA2.Department of Medical Research Center,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing,P.R.China3.Department of Medical Research Center,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital(Dongdan Campus),Chinese Academy of Medical Sciences&Peking Union Medical College,No.1 Shuaifuyuan Wangfujing,Dongcheng District,Beijing 100730,P.R.China;Tsinghua University-Peking University Joint Center for Life Sciences,Tsinghua University,Beijing 100084,P.R.China
摘要：Currently,coronavirus disease 2019(COVID-19)is still spreading in a global scale,exerting a massive health and socioeconomic crisis.Deep insights into the molecular functions of the viral proteins and the pathogenesis of this infectious disease are urgently needed.In this review,we comprehensively describe the proteome of severe acute res-piratory syndrome coronavirus 2(SARS-CoV-2)and summa-rize their protein interaction map with host cells.In the protein interaction network between the virus and the host,a total of 787 host prey proteins that appeared in at least two studies or were verified by co-immunoprecipitation experi-ments.Together with 29 viral proteins,a network of 1762 proximal interactions were observed.We also review the proteomics results of COVID-19 patients and proved that SARS-CoV-2 hijacked the host's translation system,post-translation modification system,and energy supply system via viral proteins, resulting in various immune disorders, multiple cardiomyopathies, and cholesterol metabolism diseases.
机标关键词：sars-cov-2proteomicscovid-19researchdisease
论文发表日期：2022-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：19( 427-445 )
英文信息