DOI: 10.1515/mr-2022-0027
Developmental origins of adult diseases
Jiaying Mo1
Xuanqi Liu2
Yutong Huang2
Renke He1
Yu Zhang3
Hefeng Huang4
1.Department of Obstetrics and Gynecology,The Fourth Affiliated Hospital,International Institutes of Medicine,Zhejiang University School of Medicine,Yiwu,Zhejiang Province,China2.The Key Laboratory of Reproductive Genetics(Zhejiang University),Ministry of Education,Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China3.Obstetrics and Gynecology Hospital,Institute of Reproduction and Development,Fudan University,No.131 Dong'an Road,Xuhui District,Shanghai 200032,China4.Department of Obstetrics and Gynecology,The Fourth Affiliated Hospital,International Institutes of Medicine,Zhejiang University School of Medicine,Yiwu 322000,Zhejiang Province,China
摘要：The occurrence and mechanisms of develop-mental adult diseases have gradually attracted attention in recent years.Exposure of gametes and embryos to adverse environments,especially during plastic development,can alter the expression of certain tissue-specific genes,leading to increased susceptibility to certain diseases in adulthood,such as diabetes,cardiovascular disease,neuropsychiatric,and reproductive system diseases,etc.The occurrence of chronic disease in adulthood is partly due to genetic factors,and the remaining risk is partly due to environmental-dependent epigenetic information alteration,including DNA methylation,histone modifica-tions,and noncoding RNAs.Changes in this epigenetic information potentially damage our health,which has also been supported by numerous epidemiological and animal studies in recent years.Environmental factors functionally affect embryo development through epimutation,trans-mitting diseases to offspring and even later generations.This review mainly elaborated on the concept of develop-mental origins of adult diseases,and revealed the epigenetic mechanisms underlying these events,discussed the theoretical basis for the prevention and treatment of related diseases.
机标关键词：adultdevelopmentaldiseasesorigins
论文发表日期：2022-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：21( 450-470 )
英文信息