DOI: 10.1515/mr-2022-0019
Fibroblast growth factor 21 and dietary interventions:what we know and what we need to know next
Tianru Jin
Division of Advanced Diagnostics,Toronto General Hospital Research Institute,University Health Network,101 College St.,Toronto M5G 1L7,Canada
摘要：Dietary interventions include the change of dietary styles,such as fasting and dietary or nutrient restrictions;or the addition of plant-derived compounds(such as poly-phenols known as curcumin,resveratrol,or anthocyanin,or other nutraceuticals)into the diet.During the past a few decades,large number of studies have demonstrated thera-peutic activities of these dietary interventions on metabolic and other diseases in human subjects or various animal models.Mechanisms underlying those versatile therapeutic activities,however,remain largely unclear.Interestingly,recent studies have shown that fibroblast growth factor 21(FGF21),a liver-derived hormone or hepatokine,mediates metabolic beneficial effects of certain dietary polyphenols as well as protein restriction.Here I have briefly summarized functions of FGF21,highlighted related dietary interventions,and presented literature discussions on role of FGF21 in mediating function of dietary polyphenol intervention and protein restriction.This is followed by presenting my perspective view,with the involvement of gut microbiota.It is anticipated that further breakthroughs in this field in the near future will facilitate conceptual merge of classical medicine and modern medicine.
机标关键词：fibroblastwhatgrowthnextdietaryfactorinterventionsknow
论文发表日期：2022-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 524-530 )
英文信息