DOI: 10.1515/mr-2022-0022
Hypothalamic GABAergic neurocircuitry in the regulation of energy homeostasis and sleep/wake control
Hong Jiang
Department of Neurobiology,School of Basic Medical Sciences,Neuroscience Research Institute,Peking University,No.38,Xueyuan Road,Haidian District,Beijing 100083,China
摘要：Gamma-aminobutyric acid(GABAergic)neuron,as one of important cell types in synaptic transmission,has been widely involved in central nervous system(CNS)regulation of organismal physiologies including cognition,emotion,arousal and reward.However,upon their distri-bution in various brain regions,effects of GABAergic neurons in the brain are very diverse.In current report,we will present an overview of the role of GABAergic mediated inhibitory neurocircuitry in the hypothalamus,underlying mechanism of feeding and sleep homeostasis as well as the characteristics of latest transcriptome profile in order to call attention to the GABAergic system as potentially a promising pharmaceutical intervention or a deep brain stimulation target in eating and sleep disorders.
机标关键词：controlenergygabaergichomeostasishypothalamicneurocircuitryregulationsleep
论文发表日期：2022-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 531-540 )
英文信息