DOI: 10.1515/mr-2022-0030
Understanding recurrent pregnancy loss:recent advances on its etiology,clinical diagnosis,and management
Chunwei Cao1
Shiyu Bai2
Jing Zhang3
Xiaoyue Sun3
Anming Meng4
Hui Chen5
1.Medical Research Center,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510000,Guangdong Province,China;Guangzhou Laboratory,Guangzhou 510000,Guangdong Province,China;Center for Reproductive Genetics and Reproductive Medicine,Sun Yat-Sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510000,Guangdong Province,China2.Reproductive Medicine Center,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,Guangdong Province,China3.Medical Research Center,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangdong Province,China;Center for Reproductive Genetics and Reproductive Medicine,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou,Guangdong Province,China4.Guangzhou laboratory,Guangzhou,Guangdong Province,China5.Reproductive Medicine Center,Sun Yat-sen Memorial Hospital,Sun Yat-sen University 107 Yanjiang,Guangzhou 510000,Guangdong Province,China
摘要：Recurrent pregnancy loss(RPL)has become an important reproductive health issue worldwide.RPL affects about 2%-3%of reproductive-aged women,and makes serious threats to women's physical and mental health.However,the etiology of approximately 50%of RPL cases remains unknown(unexplained RPL),which poses a big challenge for clinical management of these patients.RPL has been widely regarded as a complex disease where its etiology has been attributed to numerous factors.Heretofore,various risk factors for RPL have been identified,such as maternal ages,genetic factors,anatomical structural abnormalities,endocrine dysfunction,prethrombotic state,immunological fac-tors,and infection.More importantly,development and applications of next generation sequencing technology have significantly expanded opportunities to discover chromosomal aberrations and single gene variants respon-sible for RPL,which provides new insight into its pathogenic mechanisms.Furthermore,based upon patients'diagnostic evaluation and etiologic diagnosis,specific therapeutic recommendations have been established.This review will highlight current understanding and recent advances on RPL,with a special focus on the immunological and genetic etiologies,clinical diagnosis and therapeutic management.
机标关键词：managementclinicallossadvancesdiagnosisetiologypregnancyrecent
论文发表日期：2022-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：20( 570-589 )
英文信息