DOI: 10.1515/mr-2022-0031
Ovarian aging:mechanisms and intervention strategies
Zhengmao Zhu1
Wanxue Xu2
Lin Liu3
1.Haihe Laboratory of Cell Ecosystem,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China;Department of Genetics and Cell Biology,College of Life Science,Nankai University,94 Weijing Road,Tianjin 300071,China2.Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing,China3.Haihe Laboratory of Cell Ecosystem,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China;Department of Genetics and Cell Biology,College of Life Science,Nankai University,94 Weijing Road,Tianjin 300071,China;State Key Laboratory of Medicinal Chemical Biology,Nankai University,Tianjin 300350,China;Tianjin Union Medical Center,Institute of Translational Medicine,Nankai University,Tianjin 300000,China
摘要：Ovarian reserve is essential for fertility and influences healthy aging in women.Advanced maternal age correlates with the progressive loss of both the quantity and quality of oocytes.The molecular mechanisms and various contributing factors underlying ovarian aging have been uncovered.In this review,we highlight some of critical factors that impact oocyte quantity and quality during aging.Germ cell and follicle reserve at birth de-termines reproductive lifespan and timing the menopause in female mammals.Accelerated diminishing ovarian reserve leads to premature ovarian aging or insufficiency.Poor oocyte quality with increasing age could result from chro-mosomal cohesion deterioration and misaligned chromo-somes,telomere shortening,DNA damage and associated genetic mutations,oxidative stress,mitochondrial dysfunc-tion and epigenetic alteration.We also discuss the interven-tion strategies to delay ovarian aging.Both the efficacy of senotherapies by antioxidants against reproductive aging and mitochondrial therapy are discussed.Functional oocytes and ovarioids could be rejuvenated from pluripotent stem cells or somatic cells.We propose directions for future interventions.As couples increasingly begin delaying parenthood in life worldwide,understanding the molecular mechanisms during female reproductive aging and potential intervention strategies could benefit women in making earlier choices about their reproductive health.
机标关键词：strategiesaginginterventionmechanismsovarian
论文发表日期：2022-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：21( 590-610 )
英文信息