DOI: 10.1515/mr-2022-0032
Atypical functions of xenobiotic receptors in lipid and glucose metabolism
Jingyuan Wang1
Peipei Lu1
Wen Xie2
1.Center for Pharmacogenetics and Department of Pharmaceutical Sciences,University of Pittsburgh,Pittsburgh,PA,USA2.Center for Pharmacogenetics and Department of Pharmaceutical Sciences,University of Pittsburgh,Pittsburgh,PA 15261,USA;Department of Pharmacology and Chemical Biology,University of Pittsburgh,Pittsburgh,PA 15261,USA
摘要：Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors,the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics.Emerging evidence suggests that"xenobiotic receptors"also have diverse endobiotic functions,including their effects on lipid metabolism and energy metabolism.Dyslipidemia is a major risk factor for cardiovascular disease,diabetes,obesity,metabolic syndrome,stroke,nonalcoholic fatty liver disease(NAFLD),and nonalcoholic steatohepatitis(NASH).Understanding the molecular mechanism by which transcriptional factors,including the xenobiotic receptors,regulate lipid homeostasis will help to develop preventive and therapeutic approaches.This review describes recent advances in our understanding the atypical roles of three xenobiotic receptors:aryl hydrocarbon receptor(AhR),pregnane X receptor(PXR),and constitutive androstane receptor(CAR),in metabolic disorders,with a particular focus on their effects on lipid and glucose metabolism.Collectively,the literatures suggest the potential values of AhR,PXR and CAR as therapeutic targets for the treatment of NAFLD,NASH,obesity and diabetes,and cardiovascular diseases.
机标关键词：glucoseatypicalfunctionslipidmetabolismreceptorsxenobiotic
论文发表日期：2022-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 611-624 )
英文信息