DOI: 10.1515/mr-2022-0048
Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy
Yuanzhen Su1
Guanyu Jin2
Huicong Zhou3
Zhaofan Yang3
Lanqing Wang3
Zi Mei3
Qionghua Jin4
Shixian Lv5
Xuesi Chen6
1.Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,China;School of Materials Science and Engineering,Peking University,Beijing,China;School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei,Anhui Province,China2.School of Materials Science and Engineering,Peking University,Beijing,China;Department of Chemistry,Capital Normal University,Beijing,China3.School of Materials Science and Engineering,Peking University,Beijing,China4.Department of Chemistry,Capital Normal University,Beijing,China5.School of Materials Science and Engineering,Peking University,No.5 Yiheyuan Road,Beijing 100871,China6.Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,5625 Renmin Street,Changchun 130022,China;School of Materials Science and Engineering,Peking University,Beijing 100871,China;School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,Anhui Province,China
摘要：The complexity of the tumor microenvironment(TME)severely hinders the therapeutic effects of various cancer treatment modalities.The TME differs from normal tissues owing to the presence of hypoxia,lowpH,and immune-suppressive characteristics.Modulation of the TME to reverse tumor growth equilibrium is considered an effective way to treat tumors.Recently,polymeric nanomedicines have been widely used in cancer therapy,because their synthesis can be controlled and they are highly modifiable,and have demon-strated great potential to remodel the TME.In this review,we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME,aiming to provide in-sights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.
机标关键词：developmentenvironmentimprovedmicrocancertumormodulatingnanomedicines
论文发表日期：2023-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：27( 4-30 )
英文信息