DOI: 10.1515/mr-2022-0020
Ultrasound contrast agents from microbubbles to biogenic gas vesicles
Wenlong Zeng1
Xiuli Yue2
Zhifei Dai3
1.Department of Biomedical Engineering,College of Future Technology,Peking University,Beijing,China2.School of Environment,Harbin Institute of Technology,No.92 Xidazhi Street,Nangang District,Harbin 150001,Heilongjiang Province,China3.Department of Biomedical Engineering,College of Future Technology,Peking University,No.5 Yiheyuan Road,Haidian District,Beijing 100871,China
摘要：Microbubbles have been the earliest and most widely used ultrasound contrast agents by virtue of their unique features:such as non-toxicity,intravenous inject-ability,ability to cross the pulmonary capillary bed,and significant enhancement of echo signals for the duration of the examination,resulting in essential preclinical and clinical applications.The use of microbubbles functional-ized with targeting ligands to bind to specific targets in the bloodstream has further enabled ultrasound molecular imaging.Nevertheless,it is very challenging to utilize targeted microbubbles for molecular imaging of extra-vascular targets due to their size.A series of acoustic nanomaterials have been developed for breaking free from this constraint.Especially,biogenic gas vesicles,gas-filled protein nanostructures from microorganisms,were engineered as the first biomolecular ultrasound contrast agents,opening the door for more direct visual-ization of cellular and molecular function by ultrasound imaging.The ordered protein shell structure and unique gas filling mechanism of biogenic gas vesicles endow them with excellent stability and attractive acoustic responses.What's more,their genetic encodability enables them to act as acoustic reporter genes.This article reviews the upgrading progresses of ultrasound contrast agents from microbubbles to biogenic gas vesicles,and the opportu-nities and challenges for the commercial and clinical translation of the nascent field of biomolecular ultrasound.
机标关键词：contrastultrasoundagentsfrombiogenicmicrobubblesvesicles
论文发表日期：2023-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：18( 31-48 )
英文信息