DOI: 10.1515/mr-2022-0044
Precise genome editing with base editors
Hongcai Liu1
Yao Zhu1
Minjie Li1
Zhimin Gu2
1.Institute of Systems Medicine,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China;Suzhou Institute of Systems Medicine,Suzhou,Jiangsu Province,China2.Institute of Systems Medicine,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100005,China;Suzhou Institute of Systems Medicine,Suzhou 215123,Jiangsu Province,China
摘要：Single-nucleotide variants account for about half of known pathogenic genetic variants in human.Genome editing strategies by reversing pathogenic point mutations with minimum side effects have great therapeutic potential and are now being actively pursued.The emerge of precise and efficient genome editing strategies such as base editing and prime editing provide powerful tools for nucleotide conversion without inducing double-stranded DNA breaks(DSBs),which have shown great potential for curing genetic disorders.A diverse toolkit of base editors has been devel-oped to improve the editing efficiency and accuracy in different context of application.Here,we summarized the evolving of base editors(BEs),their limitations and future perspective of base editing-based therapeutic strategies.
机标关键词：genomebasewitheditingeditorsprecise
论文发表日期：2023-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 75-84 )
英文信息