DOI: 10.1515/mr-2023-0002
Modulation of macrophage polarization by iron-based nanoparticles
He Ding1
Yuxin Zhang1
Yu Mao2
Yan Li1
Yan Shen3
Jingyi Sheng4
Ning Gu5
1.Jiangsu Key Laboratory for Biomaterials and Devices,School of Biological Science and Medical Engineering,Southeast University,Nanjing,Jiangsu Province,China2.Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing,Jiangsu Province,China3.School of Biomedical Engineering and Informatics,Nanjing Medical University,Nanjing,Jiangsu Province,China4.Jiangsu Key Laboratory for Biomaterials and Devices,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210009,Jiangsu Province,China5.Jiangsu Key Laboratory for Biomaterials and Devices,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210009,Jiangsu,China;Medical School,Nanjing University,Nanjing 210093,Jiangsu Province,China
摘要：Macrophage polarization is an essential process involved in immune regulation.In response to different microenvironmental stimulation,macrophages polarize into cells with different phenotypes and functions,most typically M1(pro-inflammatory)and M2(anti-inflammatory)macro-phages.Iron-based nanoparticles have been widely explored and reported to regulate macrophage polarization for various biomedical applications.However,the influence factors and modulation mechanisms behind are complicated and not clear.In this review,we systemically summarized different iron-based nanoparticles that regulate macrophage polari-zation and function and discussed the influence factors and mechanisms underlying the modulation process.This review aims to deepen the understanding of the modulation of macrophage polarization by iron-based nanoparticles and expects to provide evidence and guidance for subsequent design and application of iron-based nanoparticles with specific macrophage modulation functions.
机标关键词：modulationiron-basedmacrophagenanoparticlespolarization
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：18( 105-122 )
英文信息