DOI: 10.1515/mr-2022-0046
Versatile biomimetic nanomedicine for treating cancer and inflammation disease
Zhiwen Zhao1
Dangge Wang2
Yaping Li3
1.State Key Laboratory of Drug Research & Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,China2.State Key Laboratory of Drug Research & Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,No.555,Rd Zuchongzhi,Pudong District,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China;Yantai Key Laboratory of Nanomedicine & Advanced Preparations,Yantai Institute of Materia Medica,Yantai 264000,Shandong Province,China3.State Key Laboratory of Drug Research & Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,No.555,Rd Zuchongzhi,Pudong District,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China;Shandong Laboratory of Yantai Drug Discovery,Bohai Rim Advanced Research Institute for Drug Discovery,Yantai 264000,Shandong Province,China
摘要：Nanosized drug delivery systems(NDDSs)have emerged as a powerful tool to optimize drug delivery in complex diseases,including cancer and inflammation.However,the therapeutic effect of NDDSs is still far from satisfactory due to their poor circulation time,low delivery efficiency,and innate toxicity.Fortunately,biomimetic ap-proaches offer new opportunities to develop nanomedicine,which is derived from a variety of native biomolecules including cells,exosomes,bacteria,and so on.Since inher-iting the superior biocompatibility and versatile functions of natural materials,biomimetic nanomedicine can mimic biological processes,prolong blood circulation,and lower immunogenicity,serving as a desired platform for precise drug delivery for treating cancer and inflammatory disease.In this review,we outline recent advances in biomimetic NDDSs,which consist of two concepts:biomimetic exterior camouflage and bioidentical molecule construction.We summarize engineering strategies that further functional-ized current biomimetic NDDSs.A series of functional bio-mimetic NDDSs created by our group are introduced.We conclude with an outlook on remaining challenges and possible directions for biomimetic NDDSs.We hope that better technologies can be inspired and invented to advance drug delivery systems for cancer and inflammation therapy.
机标关键词：versatilecancerbiomimeticdiseaseinflammationnanomedicinetreating
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：29( 123-151 )
英文信息