DOI: 10.1515/mr-2022-0047
Progress in nanoparticle-based regulation of immune cells
Ya-Nan Fan1
Gui Zhao1
Yue Zhang1
Qian-Ni Ye2
Yi-Qun Sun2
Song Shen1
Yang Liu3
Cong-Fei Xu4
Jun Wang5
1.School of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou International Campus,Guangzhou,Guangdong Province,China;National Engineering Research Center for Tissue Restoration and Reconstruction,South China University of Technology,Guangzhou,Guangdong Province,China2.School of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou International Campus,Guangzhou,Guangdong Province,China;Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education,South China University of Technology,Guangzhou,Guangdong Province,China3.Department of Biomedical Engineering,Wake Forest School of Medicine,Winston-Salem,NC,USA4.School of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou International Campus,Guangzhou 511442,Guangdong Province,China;National Engineering Research Center for Tissue Restoration and Reconstruction,South China University of Technology,Guangzhou 510006,Guangdong Province,China5.School of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou International Campus,Guangzhou 511442,Guangdong Province,China;National Engineering Research Center for Tissue Restoration and Reconstruction,South China University of Technology,Guangzhou 510006,Guangdong Province,China;Guangdong Provincial Key Laboratory of Biomedical Engineering,South China University of Technology,Guangzhou 510006,Guangdong Province,China
摘要：Immune cells are indispensable defenders of the human body,clearing exogenous pathogens and toxicities or endogenous malignant and aging cells.Immune cell dysfunction can cause an inability to recognize,react,and remove these hazards,resulting in cancers,inflammatory diseases,autoimmune diseases,and infections.Immune cells regulation has shown great promise in treating dis-ease,and immune agonists are usually used to treat cancers and infections caused by immune suppression.In contrast,immunosuppressants are used to treat inflammatory and autoimmune diseases.However,the key to maintaining health is to restore balance to the immune system,as excessive activation or inhibition of immune cells is a common complication of immunotherapy.Nanoparticles are efficient drug delivery systems widely used to deliver small molecule inhibitors,nucleic acid,and proteins.Using nanoparticles for the targeted delivery of drugs to immune cells provides opportunities to regulate immune cell func-tion.In this review,we summarize the current progress of nanoparticle-based strategies for regulating immune function and discuss the prospects of future nanoparticle design to improve immunotherapy.
机标关键词：cellsbasedimmunenanoparticleprogressregulation
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：28( 152-179 )
英文信息