DOI: 10.1515/mr-2023-0008
mRNA lipid nanoparticles induce immune tolerance to treat human diseases
Wei Cao1
Tian Xia2
1.Translational Medical Center,Zhengzhou Central Hospital,Zhengzhou University,Zhengzhou,Henan Province,China;Henan International Joint Laboratory of Bioconjugation and Protein Chemistry,Zhengzhou,Henan Province,China2.Division of NanoMedicine,Department of Medicine,University of California,570 Westwood Plaza,Los Angeles,CA 90095,USA
摘要：Rapid developments in the coronavirus disease 2019(COVID-19)mRNA vaccine showcased the power of lipid nanoparticle(LNP)delivery systems in fighting infectious diseases.In addition,mRNA therapeutics are also in devel-opment for cancer immunotherapy.Recently,mRNA ther-apy has been expanded to induce immune tolerance,the opposite of immune-boosting effects,to treat diseases involving enhanced immune responses including allergies and autoimmune diseases.mRNA LNPs have been used to treat peanut allergy by us and autoimmune experimental autoimmune encephalomyelitis by Ugur Sahin.It is expected that more and more research is going to delve into the im-mune tolerance field for allergies and autoimmune diseases,where effective therapies are in short supply.
机标关键词：tolerancehumanmrnatreatdiseasesimmuneinducelipid
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 180-183 )
英文信息