DOI: 10.1515/mr-2023-0020
Lipid-based nanoparticles for cancer immunotherapy
Shumin Fan1
Huize Han1
Zhicheng Yan1
Yao Lu1
Bing He2
Qiang Zhang2
1.Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems,State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing,China2.Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems,State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,NO.38 Xueyuan Road,Beijing 100191,China;Ningbo Institute of Marine Medicine,Peking University,Ningbo 315832,Zhejiang Province,China
摘要：As the fourth most important cancer manage-ment strategy except surgery,chemotherapy and radio-therapy,cancer immunotherapy has been confirmed to elicit durable antitumor effects in the clinic by leveraging the patient's own immune system to eradicate the cancer cells.However,the limited population of patients who benefit from the current immunotherapies and the immune related adverse events hinder its development.The immunosup-pressive microenvironment is the main cause of the failure,which leads to cancer immune evasion and immunity cycle blockade.Encouragingly,nanotechnology has been engi-neered to enhance the efficacy and reduce off-target toxicity of their therapeutic cargos by spatiotemporally controlling the biodistribution and release kinetics.Among them,lipid-based nanoparticles are the first nanomedicines to make clinical translation,which are now established platforms for diverse areas.In this perspective,we discuss the available lipid-based nanoparticles in research and market here,then describe their application in cancer immunotherapy,with special emphasis on the T cells-activated and macrophages-targeted delivery system.Through perpetuating each step of cancer immunity cycle,lipid-based nanoparticles can reduce immunosuppression and promote drug delivery to trigger robust antitumor response.
机标关键词：immunotherapycancerlipid-basednanoparticles
论文发表日期：2023-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：40( 230-269 )
英文信息