DOI: 10.1515/mr-2023-0009
Stem cell-derived embryo models:a frontier of human embryology
Norio Kobayashi1
Jianping Fu2
1.Department of Mechanical Engineering,University of Michigan,Ann Arbor,MI 48109,USA;Department of Cell and Developmental Biology,University of Michigan Medical School,Ann Arbor,MI 48109,USA;Department of Biomedical Engineering,University of Michigan,Ann Arbor,MI 48109,USA2.Department of Mechanical Engineering,University of Michigan,Ann Arbor,MI,USA
摘要：Studying human development remains difficult due to limited accessibility to human embryonic tissues.Prompted by the availability of human stem cells that share molecular and cellular similarities with embryonic and extraembryonic cells in peri-implantation human embryos,researchers have now successfully developed stem cell-based human embryo models that are promising as experi-mental tools for studying early human development.In this Perspective,we discuss the current progress in mouse and human stem cell-derived embryo models and highlight their promising applications in advancing the fundamental un-derstanding of mammalian development.
机标关键词：frontierhumanstemmodelscell-derivedembryology
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 343-346 )
英文信息