DOI: 10.1515/mr-2023-0016
Human stem cell modeling of neuropsychiatric disorders:from polygenicity to convergence
Jubao Duan
Center for Psychiatric Genetics,NorthShore University Health System Research Institute,Evanston 60201,IL,USA;Department of Psychiatry and Behavioral Neuroscience,The University of Chicago,Chicago 60637,IL,USA
摘要：Neuropsychiatric disorders(NPD)are prevalent and devastating,posing an enormous socioeconomic burden to modern society.Recent genetic studies of NPD have identified a plethora of common genetic risk variants with small effect sizes and rare risk variants of high penetrance.While exciting,there is a pressing need to translate these genetic discoveries into better understanding of disease biology and more tailored clinical interventions.Human induced pluripotent stem cell(hiPSC)-derived 2D and 3D neural cultures are becoming a promising cellular model for bridging the gap between genetic findings and disease biology for NPD.Leveraging the accessibility of patient bio-specimen to convert into stem cells and the power of genome editing technology to engineer disease risk variants,hiPSC model holds the promise to disentangle the disease poly-genicity,model genetic interaction with environmental factors,and uncover convergent gene pathways that may be targeted for more tailored clinical intervention.
机标关键词：convergencemodelinghumanstemropscellfromdisorders
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 347-350 )
英文信息