DOI: 10.1515/mr-2023-0010
Enrichment of nano delivery platforms for mRNA-based nanotherapeutics
Xiao Liu1
Xu Zhang2
Jiulong Li2
Huan Meng3
1.Department of Gastroenterology,Beijing Hospital,National Center of Gerontology,Institute of Geriatrics Medicine,Chinese Academy of Medical Sciences,Beijing,China2.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology,Beijing,China;University of Chinese Academy of Sciences,Beijing,China3.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology,11 Zhongguancunbeiyitiao,Haidian District,Beijing 100190,China;University of Chinese Academy of Sciences,Beijing 100049,China
摘要：Lipid-based nanoparticles(LNP)have shown significant progress in delivering mRNA for therapeutics,particularly with the success of coronavirus disease 2019(COVID-19)vaccines.However,there are still challenges,such as organ-specific targeting,sustained protein expression,immunogenicity,and storage that need to be addressed.Therefore,there is interest in developing additional nano drug delivery systems(DDS)to comple-ment LNP technology.Some of these include polymer,lipid-polymer hybrid,organic/inorganic hybrid nano-structure,and inorganic nanoparticle.In our opinion,LNP technology may not be suitable for every disease scenario in categories such as infection disease,cancer,pulmonary disease,autoimmune disorders and genetic rare disease(among others).This is because different diseases may require distinct administration routes,doses,and treat-ment durations,as well as considerations for biological barriers that may lower the efficacy and/or exert safety concern.In this perspective,we will highlight the need and potential for enhancing the diversity of nano delivery platforms for mRNA-based nanotherapeutics.
机标关键词：nanodeliveryenrichmentmrna-basedplatformstherapeutics
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 356-361 )
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