DOI: 10.1515/mr-2023-0034
Macrophages and microglia in inflammation and neuroinflammation underlying different pain states
Ouyang Chen1
Xin Luo2
Ru-Rong Ji3
1.Department of Anesthesiology,Center for Translational Pain Medicine,Duke University Medical Center,Durham,NC,USA;Department of Cell Biology,Duke University Medical Center,Durham,NC,USA2.Department of Anesthesiology,Center for Translational Pain Medicine,Duke University Medical Center,Durham,NC,USA;Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence,Southern Medical University,Guangzhou,Guangdong Province,China3.Department of Anesthesiology,Center for Translational Pain Medicine,Duke University Medical Center,Durham,NC 27710,USA;Department of Cell Biology,Duke University Medical Center,Durham,NC 27710,USA;Department of Neurobiology,Duke University Medical Center,Durham,NC 27710,USA
摘要：Pain is a main symptom in inflammation,and inflammation induces pain via inflammatory mediators acting on nociceptive neurons.Macrophages and microglia are distinct cell types,representing immune cells and glial cells,respectively,but they share similar roles in pain regulation.Macrophages are key regulators of inflammation and pain.Macrophage polarization plays different roles in inducing and resolving pain.Notably,macrophage polarization and phago-cytosis can be induced by specialized pro-resolution mediators(SPMs).SPMs also potently inhibit inflammatory and neuro-pathic pain via immunomodulation and neuromodulation.In this review,we discuss macrophage signaling involved in pain induction and resolution,as well as in maintaining physio-logical pain.Microglia are macrophage-like cells in the central nervous system(CNS)and drive neuroinflammation and pathological pain in various inflammatory and neurological disorders.Microglia-produced inflammatory cytokines can potently regulate excitatory and inhibitory synaptic trans-mission as neuromodulators.We also highlight sex differences in macrophage and microglial signaling in inflammatory and neuropathic pain.Thus,targeting macrophage and microglial signaling in distinct locations via pharmacological approaches,including immunotherapies,and non-pharmacological ap-proaches will help to control chronic inflammation and chronic pain.
机标关键词：differenteuroinflammationmacrophagesmicrogliapainstatesunderlying
论文发表日期：2023-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：27( 381-407 )
英文信息