DOI: 10.1515/mr-2023-0013
Nanostructured boron agents for boron neutron capture therapy:a review of recent patents
Xiyin Zhang1
Yusheng Lin1
Narayan S.Hosmane2
Yinghuai Zhu3
1.Shenzhen HEC Industrial Development Co.,Ltd.,Shenzhen,Guangdong Province,China2.Department of Chemistry and Biochemistry,Northern Illinois University,DeKalb,IL,USA3.Sunshine Lake Pharma Co. Ltd,No. 368 Zhen'an Middle Road,Dongguan 523871,Guangdong Province,China
摘要：Boron neutron capture therapy(BNCT)is a potential radiation therapy modality for cancer,and tumor-targeted stable boron-10(10B)delivery agents are an important component of BNCT.Currently,two low-molecular-weight boron-containing compounds,sodium mercaptoundecahydro-closo-dodecaborate(BSH)and boronophenylalanine(BPA),are mainly used in BNCT.Although both have suboptimal tu-mor selectivity,they have shown some therapeutic benefit in patients with high-grade glioma and several other tumors.To improve the efficacy of BNCT,great efforts have been devoted for the development of new boron delivery agents with better uptake and favorable pharmacokinetic profiles.This article reviews the application and research progress of boron nano-materials as boron carriers in boron neutron capture therapy and hopes to stimulate people's interest in nanomaterial-based delivery agents by summarizing various kinds of boron nanomaterial patents disclosed in the past decade.
机标关键词：neutronreviewagentsboroncapturenanostructuredpatentsrecent
论文发表日期：2023-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：19( 425-443 )
英文信息