DOI: 10.1515/mr-2023-0046
Imaging and spatial omics of kidney injury:significance,challenges,advances and perspectives
Zehua Li1
Yao Lu1
Li Yang2
1.Renal Division,Peking University Institute of Nephrology,Peking University First Hospital,Beijing,China;Key Laboratory of Renal Disease-Ministry of Health of China,Key Laboratory of CKD Prevention and Treatment(Peking University)-Ministry of Education of China,Peking University First Hospital,Beijing,China;Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases-Chinese Academy of Medical Sciences,Peking University First Hospital,Beijing,China2.Renal Division,Peking University Institute of Nephrology,Peking University First Hospital,Beijing 100034,China and Key Laboratory of Renal Disease-Ministry of Health of China,Key Laboratory of CKD Prevention and Treatment(Peking University)-Ministry of Education of China,Peking University First Hospital,Beijing 100034,China;Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases-Chinese Academy of Medical Sciences,Peking University First Hospital,Xishiku Street#8,Beijing 100034,China
摘要：The kidneys are susceptible to a range of insults that can cause damage to them.Early diagnosis,timely prevention,and proper treatment are crucial for improving the outcome of kidney injury.However,the complexity of renal structure and function makes it difficult to reach the demand of early detection and comprehensive evaluation of kidney injury.No successful drug therapy caused by the elaborate pathogenesis mechanism network of kidney injury calls for a systematical interpretation in mechanism researches.Recent advances in renal imaging and omics studies have provided novel views and deeper insights into kidney injury,but also raise challenges in reaching a comprehensive cellular and molecular atlas of kidney injury.Progresses in imaging and omics of kidney injury are being made in various directions,with the initiative of construction a high-resolution structural atlas of kid-ney,dynamic and non-invasive evaluation of renal func-tion,and systematic establishment of spatially resolved molecular atlas by transcriptomics and metabolomics.With the limitations of a single modality,novel multi-modal integration technologies of imaging and omics are being attempted to achieve a systematic description of nephropathy mechanisms.Further extensive efforts in renal multimodal imaging and omics studies are extremely required to deepen our understanding on kidney injury in the context of diagnostic,mechanistic and therapeutic perspectives.
机标关键词：significanceimagingspatialkidneyadvanceschallengesinjuryomics
论文发表日期：2023-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 514-520 )
英文信息