DOI: 10.1515/mr-2023-0059
The new era of cardiovascular research:revolutionizing cardiovascular research with 3D models in a dish
Yuan Yang1
Hao Yang1
Fedir N.Kiskin1
Joe Z.Zhang2
1.Institute of Neurological and Psychiatric Disorders,Shenzhen Bay Laboratory,Shenzhen,Guangdong Province,China2.Institute of Neurological and Psychiatric Disorders,Shenzhen Bay Laboratory,Shenzhen 518132,Guangdong Province,China
摘要：Cardiovascular research has heavily relied on studies using patient samples and animal models.However,patient studies often miss the data from the crucial early stage of cardiovascular diseases,as obtaining primary tis-sues at this stage is impracticable.Transgenic animal models can offer some insights into disease mechanisms,although they usually do not fully recapitulate the phenotype of car-diovascular diseases and their progression.In recent years,a promising breakthrough has emerged in the form of in vitro three-dimensional(3D)cardiovascular models utilizing human pluripotent stem cells.These innovative models recreate the intricate 3D structure of the human heart and vessels within a controlled environment.This advancement is pivotal as it addresses the existing gaps in cardiovascular research,allowing scientists to study different stages of cardiovascular diseases and specific drug responses using human-origin models.In this review,we first outline various approaches employed to generate these models.We then comprehensively discuss their applications in studying car-diovascular diseases by providing insights into molecular and cellular changes associated with cardiovascular condi-tions.Moreover,we highlight the potential of these 3D models serving as a platform for drug testing to assess drug efficacy and safety.Despite their immense potential,chal-lenges persist,particularly in maintaining the complex structure of 3D heart and vessel models and ensuring their function is comparable to real organs.However,over-coming these challenges could revolutionize cardiovascu-lar research.It has the potential to offer comprehensive mechanistic insights into human-specific disease processes,ultimately expediting the development of personalized therapies.
机标关键词：researchmodelswithcardiovasculardishrevolutionizing
论文发表日期：2024-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：18( 68-85 )
英文信息