DOI: 10.1515/mr-2023-0047
Organoids as preclinical models of human disease:progress and applications
Baodan Chen1
Cijie Du1
Mengfei Wang1
Jingyi Guo2
Xingguo Liu3
1.CAS Key Laboratory of Regenerative Biology,Joint School of Life Sciences,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou Medical University,Guangzhou,China;Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine,China-New Zealand Joint Laboratory on Biomedicine and Health,CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine,GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre,Institute for Stem Cell and Regeneration,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,China;University of Chinese Academy of Sciences,Beijing,China2.Innovation Centre for Advanced Interdisciplinary Medicine,The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou,China3.CAS Key Laboratory of Regenerative Biology,Joint School of Life Sciences,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou Medical University,Guangzhou,China;Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine,China-New Zealand Joint Laboratory on Biomedicine and Health,CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine,GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre,Institute for Stem Cell and Regeneration,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,China;Centre for Regenerative Medicine and Health,Hong Kong Institute of Science & Innovation,Chinese Academy of Sciences,Hong Kong SAR,China
摘要：In the field of biomedical research,organoids represent a remarkable advancement that has the potential to revolutionize our approach to studying human diseases even before clinical trials.Organoids are essentially miniature 3D models of specific organs or tissues,enabling scientists to investigate the causes of diseases,test new drugs,and explore personalized medicine within a controlled laboratory setting.Over the past decade,organoid technology has made sub-stantial progress,allowing researchers to create highly detailed environments that closely mimic the human body.These organoids can be generated from various sources,including pluripotent stem cells,specialized tissue cells,and tumor tissue cells.This versatility enables scientists to replicate a wide range of diseases affecting different organ systems,effectively creating disease replicas in a laboratory dish.This exciting capability has provided us with unprece-dented insights into the progression of diseases and how we can develop improved treatments.In this paper,we will provide an overview of the progress made in utilizing organoids as preclinical models,aiding our understanding and providing a more effective approach to addressing various human diseases.
机标关键词：applicationshumanmodelsdiseaseorganoidspreclinicalprogress
论文发表日期：2024-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：25( 129-153 )
英文信息