DOI: 10.1515/mr-2024-0003
The role of bile acids in human aging
Lihua Jin1
Linsen Shi2
Wendong Huang3
1.Department of Diabetes Complications and Metabolism,Arthur Riggs Diabetes and Metabolism Research Institute,Beckman Research Institute,City of Hope National Medical Center,1500 E.Duarte Road,Duarte,CA 91010,USA2.Department of Diabetes Complications and Metabolism,Arthur Riggs Diabetes and Metabolism Research Institute,Beckman Research Institute,City of Hope National Medical Center,Duarte,CA,USA3.Department of Diabetes Complications and Metabolism,Arthur Riggs Diabetes and Metabolism Research Institute,Beckman Research Institute,City of Hope National Medical Center,1500 E.Duarte Road,Duarte,CA 91010,USA;Irell & Manella Graduate School of Biomedical Science,City of Hope National Medical Center,1500 E.Duarte Road,Duarte,CA 91010,USA
摘要：Bile acids are recognized as important signaling molecules that enable fine-tuned inter-communication from the liver,through the intestine,to virtually any organ,thus encouraging their pleiotropic physiological effects.Aging is a complex natural process defined as a progressive decline in cellular and organismal functions.A causal link between bile acids and the aging process is emerging.However,there are gaps in our understanding of the molecular mechanisms and precise targets responsible for the alteration of bile acid pro-files and their role in the aging process.Intestinal barrier dysfunction leads to endotoxemia,systemic inflammation,insulin resistance,diabetes,lipid accumulation,obesity and fatty liver diseases,and health decline and death.In fact,in-testinal barrier dysfunction is suggested to be an evolution-arily conserved hallmark of aging.Bile acids may modulate the aging process by regulating intestinal barrier integrity.
机标关键词：humanroleacidsagingbile
论文发表日期：2024-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 154-157 )
英文信息