DOI: 10.1515/mr-2023-0064
The molecular and cellular choreography of early mammalian lung development
Xianfa Yang1
Yingying Chen2
Yun Yang3
Shiting Li4
Panpan Mi5
Naihe Jing1
1.Guangzhou National Laboratory,No.9 XingDaoHuanBei Road,Guangzhou International Bio Island,Guangzhou 510005,Guangdong Province,China2.Guangzhou National Laboratory,Guangzhou,Guangdong Province,China3.Guangzhou National Laboratory,Guangzhou,Guangdong Province,China;Guangzhou Medical University,Guangzhou,Guangdong Province,China4.Guangzhou National Laboratory,Guangzhou,Guangdong Province,China;Institute of Biomedical Research,Yunnan University,Kunming,Yunnan Province,China5.Guangzhou National Laboratory,Guangzhou,Guangdong Province,China;Department of Histology and Embryology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong Province,China
摘要：Mammalian lung development starts from a spe-cific cluster of endodermal cells situated within the ventral foregut region.With the orchestrating of delicate choreog-raphy of transcription factors,signaling pathways,and cell-cell communications,the endodermal diverticulum extends into the surrounding mesenchyme,and builds the cellular and structural basis of the complex respiratory system.This review provides a comprehensive overview of the current molecular insights of mammalian lung devel-opment,with a particular focus on the early stage of lung cell fate differentiation and spatial patterning.Furthermore,we explore the implications of several congenital respiratory diseases and the relevance to early organogenesis.Finally,we summarize the unprecedented knowledge concerning lung cell compositions,regulatory networks as well as the promising prospect for gaining an unbiased understanding of lung development and lung malformations through state-of-the-art single-cell omics.
机标关键词：choreographydevelopmentmolecularcellularearlylungmammalian
论文发表日期：2024-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 192-206 )
英文信息