DOI: 10.1515/mr-2023-0069
DNA-based nanostructures for RNA delivery
Yuanyuan Wu1
Liangzhi Luo2
Ziyang Hao3
Dongsheng Liu4
1.Beijing SupraCirc Biotechnology Co.,Ltd,Beijing,China2.School of Pharmaceutical Sciences,Capital Medical University,Beijing,China3.School of Pharmaceutical Sciences,Capital Medical University,Beijing 100069,China4.Department of Chemistry,Engineering Research Center of Advanced Rare Earth Materials,(Ministry of Education),Tsinghua University,Beijing 100084,China
摘要：RNA-based therapeutics have emerged as a promising approach for the treatment of various diseases,including cancer,genetic disorders,and infectious diseases.However,the delivery of RNA molecules into target cells has been a major challenge due to their susceptibility to degra-dation and inefficient cellular uptake.To overcome these hurdles,DNA-based nano technology offers an unprece-dented opportunity as a potential delivery platform for RNA therapeutics.Due to its excellent characteristics such as programmability and biocompatibility,these DNA-based nanostructures,composed of DNA molecules assembled into precise and programmable structures,have garnered significant attention as ideal building materials for pro-tecting and delivering RNA payloads to the desired cellular destinations.In this review,we highlight the current prog-ress in the design and application of three DNA-based nano-structures:DNA origami,lipid-nanoparticle(LNP)technology related to frame guided assembly(FGA),and DNA hydrogel for the delivery of RNA molecules.Their biomedical appli-cations are briefly discussed and the challenges and future perspectives in this field are also highlighted.
机标关键词：deliverydna-basednanostructures
论文发表日期：2024-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：18( 207-224 )
英文信息