DOI: 10.1515/mr-2024-0020
Dysregulated bile acid homeostasis:unveiling its role in metabolic diseases
Yanyan Wang1
Huangru Xu2
Xiqiao Zhou3
Weidong Chen4
Huiping Zhou5
1.Department of Microbiology and Immunology,Virginia Commonwealth University,Richmond Veterans Affairs Medical Center,Richmond,VA,USA;School of Pharmaceutical Science,Anhui University of Chinese Medicine,Hefei,Anhui,China2.School of Life Science,Nanjing University,Nanjing,Jiangsu,China3.Department of Endocrinology,Jiangsu Province Hospital of Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing,Jiangsu,China4.School of Pharmaceutical Science,Anhui University of Chinese Medicine,Hefei,Anhui,China5.Department of Microbiology and Immunology,Virginia Commonwealth University,Richmond Veterans Affairs Medical Center,Richmond,VA 23298-0678,USA
摘要：Maintaining bile acid homeostasis is essential for metabolic health.Bile acid homeostasis encompasses a complex interplay between biosynthesis,conjugation,secretion,and reabsorption.Beyond their vital role in digestion and absorption of lipid-soluble nutrients,bile acids are pivotal in systemic metabolic regulation.Recent studies have linked bile acid dysregulation to the pathogenesis of metabolic diseases,including obesity,type 2 diabetes melli-tus(T2DM),and metabolic dysfunction-associated steatotic liver disease(MASLD).Bile acids are essential signaling molecules that regulate many critical biological processes,including lipid metabolism,energy expenditure,insulin sensitivity,and glucose metabolism.Disruption in bile acid homeostasis contributes to metabolic disease via altered bile acid feedback mechanisms,hormonal dysregu-lation,interactions with the gut microbiota,and changes in the expression and function of bile acid transporters and receptors.This review summarized the essential molecular pathways and regulatory mechanisms through which bile acid dysregulation contributes to the pathogenesis and progression of obesity,T2DM,and MASLD.We aim to underscore the significance of bile acids as potential diag-nostic markers and therapeutic agents in the context of metabolic diseases,providing insights into their application in translational medicine.
机标关键词：metabolicroleacidbilediseasesdysregulatedhomeostasisunveiling
论文发表日期：2024-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：22( 262-283 )
英文信息