DOI: 10.1515/mr-2024-0029
Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders:from molecular mechanisms to clinical implications
Jinyu Zhao1
Ping Yue1
Ningning Mi1
Matu Li2
Wenkang Fu1
Xianzhuo Zhang1
Long Gao1
Mingzhen Bai1
Liang Tian1
Ningzu Jiang1
Yawen Lu1
Haidong Ma1
Chunlu Dong1
Yong Zhang1
Hengwei Zhang1
Jinduo Zhang1
Yanxian Ren1
Azumi Suzuki3
Peng F.Wong4
Kiyohito Tanaka5
Rungsun Rerknimitr6
Henrik H.Junger7
Tan T.Cheung8
Emmanuel Melloul9
Nicolas Demartines9
Joseph W.Leung10
Jia Yao11
Jinqiu Yuan12
Yanyan Lin13
Hans J.Schlitt14
Wenbo Meng13
1.Department of General Surgery,The First Hospital of Lanzhou University,Lanzhou,Gansu,China2.Department of Gastroenterology,The First Hospital of Lanzhou University,Lanzhou,Gansu,China3.Department of Gastroenterology,Hamamatsu Medical Center,Hamamatsu,Japan4.Department of Vascular Surgery,The James Cook University Hospital,Middlesbrough,UK5.Department of Gastroenterology,Kyoto Second Red Cross Hospital,Kyoto,Japan6.Division of Gastroenterology,Department of Medicine,Faculty of Medicine,Chulalongkorn,Bangkok,Thailand;Excellence Center for Gastrointestinal Endoscopy,King Chulalongkorn Memorial Hospital,Bangkok,Thailand7.Department of Surgery,University Medical Center Regensburg,Regensburg,Germany8.Department of Surgery,The University of Hong Kong,Hong Kong,China9.Department of Visceral Surgery,Lausanne University Hospital CHUV,University of Lausanne(UNIL),Lausanne,Switzerland10.Division of Gastroenterology and Hepatology,UC Davis Medical Center and Sacramento VA Medical Center,Sacramento,CA,USA11.The First School of Clinical Medicine,Lanzhou University,Lanzhou,Gansu 730000,China;Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province,Lanzhou,Gansu 730000,China12.Clinical Research Center,Big Data Center,The Seventh Affiliated Hospital,Sun Yat-sen University,Shenzhen,Guangdong 518000,China13.Department of General Surgery,The First Hospital of Lanzhou University,Lanzhou,Gansu 730000,China14.Department of Surgery,University Medical Center Regensburg,93053 Regensburg,Germany
摘要：Fibrosis resulting from pathological repair sec-ondary to recurrent or persistent tissue damage often leads to organ failure and mortality.Biliary fibrosis is a crucial but easily neglected pathological feature in hepatobiliary disorders,which may promote the development and pro-gression of benign and malignant biliary diseases through pathological healing mechanisms secondary to biliary tract injuries.Elucidating the etiology and pathogenesis of biliary fibrosis is beneficial to the prevention and treatment of biliary diseases.In this review,we emphasized the impor-tance of biliary fibrosis in cholangiopathies and summarized the clinical manifestations,epidemiology,and aberrant cellular composition involving the biliary ductules,chol-angiocytes,immune system,fibroblasts,and the micro-biome.We also focused on pivotal signaling pathways and offered insights into ongoing clinical trials and proposing a strategic approach for managing biliary fibrosis-related cholangiopathies.This review will offer a comprehensive perspective on biliary fibrosis and provide an important reference for future mechanism research and innovative therapy to prevent or reverse fibrosis.
机标关键词：molecularfeatureclinicalfibrosisfromdisordershepatobiliaryimplications
论文发表日期：2024-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：40( 326-365 )
英文信息