DOI: 10.1515/mr-2023-0066
Improving lung allograft function in the early post-operative period through the inhibition of pyroptosis
Doug A.Gouchoe1
Zhentao Zhang2
Jung-Lye Kim1
Yong Gyu Lee1
Bryan A.Whitson1
Hua Zhu3
1.Department of Surgery,Division of Cardiac Surgery,The Ohio State University Wexner Medical Center,Columbus,OH,USA;COPPER Laboratory,The Ohio State University Wexner Medical Center,Columbus,OH,USA2.Department of Surgery,Division of Cardiac Surgery,The Ohio State University Wexner Medical Center,Columbus,OH,USA3.Department of Surgery,Division of Cardiac Surgery,The Ohio State University Wexner Medical Center,Columbus,OH 43210,USA
摘要：Lung transplantation is the only definitive ther-apy for end-stage pulmonary disease.Less than 20％of offered lungs are successfully transplanted due to a limited ischemic time window and poor donor lung quality man-ifested by pulmonary edema,hypoxia,or trauma.Therefore,poor donor organ recovery and utilization are significant barriers to wider implementation of the life-saving therapy of transplantation.While ischemia reperfusion injury(IRI)is often identified as the underlying molecular insult leading to immediate poor lung function in the post-operative period,this injury encompasses several pathways of cellular injury in addition to the recruitment of the innate immune system to the site of injury to propagate this inflammatory cascade.Pyroptosis is a central molecular inflammatory pathway that is the most significant contributor to injury in this early post-operative phase.Pyroptosis is another form of pro-grammed cell death and is often associated with IRI.The mitigation of pyroptosis in the early post-operative period following lung transplantation is a potential novel way to prevent poor allograft function and improve outcomes for all recipients.Here we detail the pyroptotic pathway,its importance in lung transplantation,and several therapeutic modalities that can mitigate this harmful inflammatory pathway.
机标关键词：pyroptosisinhibitionthroughfunctionperiodallograftearlyimproving
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 384-394 )
英文信息