DOI: 10.1515/mr-2023-0048
Complement factor H in molecular regulation of angiogenesis
Jiang Li1
Kaili Wang2
Maria N.Starodubtseva3
Eldar Nadyrov3
Carolyn M.Kapron3
Josephine Hoh4
Ju Liu5
1.Laboratory of Translational Medicine in Microvascular Regulation,Institute of Microvascular Medicine,Medical Research Center,The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital,Jinan,Shandong Province,China;Shandong Provincial Key Medical and Health Laboratory of Translational Medicine in Microvascular Aging,Jinan,Shandong Province,China;Medical Research Center,Shandong Provincial Qianfoshan Hospital,Shandong University,Jinan,Shandong Province,China2.Laboratory of Translational Medicine in Microvascular Regulation,Institute of Microvascular Medicine,Medical Research Center,The First Affiliated Hospital of Shandong First Medical University &Shandong Provincial Qianfoshan Hospital,Jinan,Shandong Province,China;Shandong Provincial Key Medical and Health Laboratory of Translational Medicine in Microvascular Aging,Jinan,Shandong Province,China3.Gomel State Medical University,Gomel,Belarus;Institute of Radiobiology of NAS of Belarus,Gomel,Belarus,Gomel State Medical University,Gomel,Belarus,Department of Biology,Trent University,Peterborough,ON,Canada4.Department of Ophthalmology,Yale School of Medicine,New Haven,CT,USA5.Laboratory of Translational Medicine in Microvascular Regulation,Institute of Microvascular Medicine,Medical Research Center,The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital,Jinan,Shandong Province 250014,China;Shandong Provincial Key Medical and Health Laboratory of Translational Medicine in Microvascular Aging,Jinan,Shandong Province 250014,China;Medical Research Center,Shandong Provincial Qianfoshan Hospital,Shandong University,Jinan,Shandong Province 250014,China
摘要：Angiogenesis,the process of formation of new capillaries from existing blood vessels,is required for multiple physiological and pathological processes.Complement factor H(CFH)is a plasma protein that inhibits the alternative pathway of the complement system.Loss of CFH enhances the alterna-tive pathway and increases complement activation fragments with pro-angiogenic capacity,including complement 3a,complement 5a,and membrane attack complex.CFH protein contains binding sites for C-reactive protein,malondialdehyde,and endothelial heparan sulfates.Dysfunction of CFH pre-vents its interaction with these molecules and initiates pro-angiogenic events.Mutations in the CFH gene have been found in patients with age-related macular degener-ation characterized by choroidal neovascularization.The Cfh-deficient mice show an increase in angiogenesis,which is decreased by administration of recombinant CFH pro-tein.In this review,we summarize the molecular mecha-nisms of the anti-angiogenic effects of CFH and the regulatory mechanisms of CFH expression.The therapeutic potential of recombinant CFH protein in angiogenesis-related diseases has also been discussed.
机标关键词：molecularangiogenesiscomplementfactorregulation
论文发表日期：2024-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 452-466 )
英文信息