DOI: 10.1515/mr-2024-0019
Cancer nuclear envelope rupture and repair in taxane resistance
Ana P.Xu1
Lucy B.Xu1
Elizabeth R.Smith2
Joshua S.Fleishman3
Zhe-Sheng Chen3
Xiang-Xi Xu4
1.University of Miami,Miami,FL,USA2.Sylvester Comprehensive Cancer Center,University of Miami Miller School of Medicine,Miami,FL,USA;and Department of Obstetrics,Gynecology and Reproductive Science,University of Miami Miller School of Medicine,Miami,FL,USA3.College of Pharmacy and Health Sciences,St.John's University,Queens New York,USA4.Sylvester Comprehensive Cancer Center,University of Miami Miller School of Medicine,Miami,FL 33136,USA;and Department of Radiation Oncology,University of Miami Miller School of Medicine,Miami,FL 33136,USA
摘要：Taxanes,including paclitaxel,docetaxel,and cab-azitaxel,are key agents in cancer treatment,often used as front-line chemotherapy drugs in combination with other agent(s)(commonly carboplatin)and as second-line treatments alone.Generally,taxanes are highly effective,but drug resistance unavoidably develops following repeated treatment.Taxanes work by binding to and stabilizing microtubules,leading to mitotic arrest,mitotic catastrophe,and micronucleation.The long-recognized mechanisms of drug resistance generally can be classified into three categories:drug efflux,microtubule polymerization,and apoptotic pathway.A recent new addition to this list is a mechanism related to the nuclear envelope,as cancer cells undergo micronucleation and nuclear membrane rupture when treated with taxanes.All these mechanisms may operate simultaneously as taxane resistance is multi-factorial.Here,we review the cell biology understanding of nuclear envelope breaking in production of micronucleation,and nuclear membrane rupture and repair,and propose that these processes are involved in taxane resistance.
机标关键词：cancerenvelopenuclearrepairresistancerupturetaxane
论文发表日期：2024-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息