DOI: 10.1515/mr-2024-0034
Mechanical force modulates inflammation and immunomodulation in periodontal ligament cells
Jira Chansaenroj1
Ravipha Suwittayarak1
Hiroshi Egusa2
Lakshman P.Samaranayake3
Thanaphum Osathanon4
1.Faculty of Dentistry,Center of Excellence for Dental Stem Cell Biology,Chulalongkorn University,Bangkok,Thailand2.Division of Molecular and Regenerative Prosthodontics,Tohoku University Graduate School of Dentistry,Sendai,Miyagi,Japan;and Center for Advanced Stem Cell and Regenerative Research,Tohoku University Graduate School of Dentistry,Sendai,Miyagi,Japan3.Dean Office and Office of Research Affairs,Faculty of Dentistry,Chulalongkorn University,Bangkok,Thailand;and Faculty of Dentistry,The University of Hong Kong,Hong Kong Special Administrative Region,China4.Faculty of Dentistry,Center of Excellence for Dental Stem Cell Biology,Chulalongkorn University,Bangkok 10700,Thailand;and Department of Anatomy,Faculty of Dentistry,Chulalongkorn University,Bangkok 10700,Thailand
摘要：Mechanical forces control a multitude of biolog-ical responses in various cells and tissues.The periodontal ligament,located between the tooth's root and alveolar bone,is a major tissue compartment that is incessantly subjected to such mechanical stimulation through either normal or abnormal oral functionality.It is now known that mechan-ical stimulation activates periodontal ligament stem cells(PDLSCs)to modulate periodontal immunity and regulate inflammation-a basic feature of periodontal disease that af-fects virtually every human during their lifetime.For instance,shear stress induces the expression of immunomodulatory-related gene,indoleamine 2,3-dioxygenase(IDO).IDO cleaves l-tryptophan,resulting in increased l-kynurenine levels that,in turn,further promote regulatory T-cell differentiation and inhibit T cell proliferation.These and other related data reinforce the notion that mechanical stimulation plays a crucial role in controlling inflammation and immunomo-dulation of periodontal tissues.Further investigations,however,are warranted to evaluate the immunomodulatory features of PDLSCs so as to understand the pathological basis of periodontal disease and translate these into clinical interventions.
机标关键词：modulationforcecellsinflammationligamentmechanicalmodulatesperiodontal
论文发表日期：2024-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息