股骨头坏死机制研究中的常见细胞及其表型
饶宇1
徐永清2
齐保闯3
贺建林2
浦路桥2
施洪鑫4
任俊筱5
李川6
1.650500 云南省,昆明医科大学研究生院2.650032 昆明,中国人民解放军联勤保障部队第九二○医院骨科3.650500 云南省,昆明医科大学研究生院;650032 昆明,中国人民解放军联勤保障部队第九二○医院骨科4.671003 云南省,大理大学临床医学院5.650500 昆明,云南中医药大学第一临床医学院6.650032 昆明,中国人民解放军联勤保障部队第九二○医院骨科;650201 昆明,中国科学院昆明动物研究所
摘要：Recent focus on basic research into femoral head osteonecrosis(ONFH)has unveiled the significance of various cells in disease onset,progression,and treatment.These include osteoblasts and osteoclasts for bone homeostasis,endothelial cells for new blood vessel formation,and macrophages for immune responses.Cell phenotypes,indicative of changes when cells are influenced by disease-specific molecules,are fundamental for molecular function analysis.Research has commonly explored phenotypes like cell growth,death,and movement,with growing interest in macrophage polarization and iron-induced cell death.This review encapsulates the key cellular players and their phenotypes in ONFH research,guiding future directions in the disease mechanism studies.
关键词：股骨头坏死表型细胞综述
分类号：R684(骨科学（运动系疾病、矫形外科学）)
资助基金：昆医联合专项-面上项目(202001AC070337)云南省科技人才与平台计划(202105AD160027)
论文发表日期：2024-10-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 795-802 )
英文信息