成纤维样滑膜细胞在骨关节炎中的研究进展
王佳豪
高焱
李翀
郝彦明
215300 江苏省,南京医科大学姑苏学院,昆山市第一人民医院关节外科
摘要：Osteoarthritis(OA)is a common degenerative joint disease that has shown increasing prevalence and a trend toward younger onset in recent years,severely impairing quality of life and imposing a significant socioeconomic burden.Fibroblast-like synoviocytes(FLS)have emerged as critical effector cells in OA due to their central role in maintaining synovial inflammation,promoting joint destruction,and driving subchondral bone remodeling.Although substantial progress has been made in understanding the mechanisms of FLS pathological activation,a comprehensive,structured review and integrative framework is still lacking.In this review,we propose a three-tiered model"Input-Regulation-Output"to systematically summarize the multilevel regulatory network underlying the transition of FLS from a quiescent to a pathological state.The input layer includes extracellular stimuli such as proinflammatory cytokines,chemokines,and damage-associated molecular patterns;the regulatory layer covers gene expression mechanisms mediated by transcription factors and non-coding RNAs;and the output layer focuses on altered protein expression,post-translational modifications,and phenotypic remodeling.Additionally,we integrate recent findings on FLS interactions with macrophages,chondrocytes,and osteoclasts within the OA joint microenvironment to depict a coordinated pathogenic network.By constructing a functional atlas of FLS pathological activation,this review aims to identify key regulatory nodes in OA progression and provide a theoretical basis for the discovery of early diagnostic biomarkers and the development of targeted therapeutic strategies.
关键词：骨关节炎滑膜细胞细胞微环境基因表达调控细胞间通讯综述
分类号：R684.3(骨科学（运动系疾病、矫形外科学）)
资助基金：昆山市级科技计划项目(KS2405)昆山市级科技计划项目(KS2312)
论文发表日期：2025-10-19
在线出版日期：2025-11-06（本平台首次上网日期，不代表文献的发表时间）
页数：8( 935-942 )
英文信息