椎间盘退变中的丝裂原活化蛋白激酶信号通路
赵欢1
左媛2
韩汶延2
1.010107 呼和浩特,内蒙古医科大学2.010000 呼和浩特,内蒙古医科大学第二附属医院检验科
摘要：Intervertebral disc degeneration is a common degenerative disease that is the main cause of low back pain and seriously affects the quality of life of patients.Recent studies have shown that the pathology of IDD is driven by a vicious cycle of"immune-metabolic-aging"interactions.This process is closely linked to multiple stressors that activate the mitogen-activated protein kinase(MAPK)pathway,which mediates ECM degradation,apoptosis,cellular senescence,autophagy,oxidative stress,and ferroptosis,thereby accelerating the progression of IDD.This article reviews the effects of MAPK activation on the pathological process of IDD and proposes potential therapeutic targets.The aim is to provide a reference for in-depth research on the mechanism of action of this signaling pathway and targeted therapy for IDD in the future.
关键词：丝裂原活化蛋白激酶椎间盘退行性变髓核综述
分类号：R681.5(骨科学（运动系疾病、矫形外科学）)
资助基金：内蒙古医科大学面上项目(YKD2022MS036)内蒙古自治区自然科学基金项目(2022MS08016)
论文发表日期：2025-10-19
在线出版日期：2025-11-06（本平台首次上网日期，不代表文献的发表时间）
页数：5( 948-952 )
英文信息