胆碱能抗炎通路治疗骨关节炎的研究进展
李宁1
靳巧锋2
李佩1
刘贝贝2
左伟3
1.430079 湖北省,武汉体育学院2.430022 武汉,华中科技大学同济医学院附属协和医院超声医学科3.430033 湖北省,武汉市第四医院关节外科
摘要：The cholinergic anti-inflammatory pathway(CAP)has garnered significant attention in recent years as a novel therapeutic strategy for osteoarthritis(OA).This review aims to summarize and evaluate the research progress on the application of CAP in the treatment of OA.The CAP alleviates inflammatory responses and pain associated with OA by activating cholinergic receptors,thereby improving joint function in patients.Mechanistic studies have demonstrated that cholinergic receptor agonists can inhibit the release of inflammatory mediators,reduce arthritic inflammation,and modulate the excitability of nociceptive neurons.Animal experiments have shown that cholinergic receptor agonists mitigate inflammation and pain in arthritic mice while promoting cartilage repair and regeneration.However,further research is needed to elucidate its mechanisms of action,advantages,and potential side effects,as well as to conduct larger-scale clinical trials to validate its efficacy.The investigation of CAP as a treatment for OA offers new therapeutic options for patients and provides a promising direction for the development of future treatment strategies.
关键词：神经免疫调节骨关节炎胆碱能抗炎通路综述
分类号：R684.3(骨科学（运动系疾病、矫形外科学）)
论文发表日期：2026-01-19
在线出版日期：2026-03-09（本平台首次上网日期，不代表文献的发表时间）
页数：6( 91-96 )
英文信息