Effect of erythropoietin combined with hypothermia on serum tau protein levels and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy
Hong-yan Lv
Su-jing Wu
Qiu-li Wang
Li-hong Yang
Peng-shun Ren
Bao-jun Qiao
Zhi-ying Wang
Jia-hong Li
Xiu-ling Gu
Lian-xiang Li
摘要：Although hypothermia therapy is effective to treat neonatal hypoxic-ischemic encephalopathy, many neonatal patients die or suffer from severe neurological dysfunction. Erythropoietin is considered one of the most promising neuroprotective agents. We hypothesized that erythropoietin combined with hypothermia will improve efficacy of neonatal hypoxic-ischemic encephalopathy treatment. In this study, 41 neonates with moderate/severe hypoxic-ischemic encephalopathy were randomly divided into a control group (hypothermia alone for 72 hours, n = 20) and erythropoietin group (hypothermia + erythropoietin 200 IU/kg for 10 days, n = 21). Our results show that compared with the control group, serum tau protein levels were lower and neonatal behavioral neurological assessment scores higher in the eryth-ropoietin group at 8 and 12 days. However, neurodevelopmental outcome was similar between the two groups at 9 months of age. Thesefindings suggest that erythropoietin combined with hypothermia reduces serum tau protein levels and improves neonatal behavioral neu-rology outcome but does not affect long-term neurodevelopmental outcome.
机标关键词：tau proteinneuroprotective agentshypothermia therapy
资助基金：This study was supported by a grant from the Health and Family Planning Commission of Hebei Province of China, (No. 20150033)a grant from the Science and Technology Research and Development Project of Handan City of Hebei Province of China, (No. 152810879-6)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1655-1663 )
英文信息